Antelope Creek rises four miles west of Lometa in northwest Lampasas County (at 31°18' N, 98°27' W) and runs southwest for ten miles to its mouth on the Colorado River, five miles west of Lometa (at 31°12' N, 98°32' W). North Antelope Creek rises one mile east of Scallorn in southeast Mills County (at 31°18' N, 98°30' W) and runs southeast six miles. The two creeks join near the county line in Lampasas County (at 31°16' N, 98°30' W). Antelope Creek is intermittent in its upper reaches. It crosses an area of steep slopes and benches and flat to rolling terrain surfaced by sandy and clay loams that support juniper, oak, live oak, mesquite, elm, and grasses.