William Gates, Old Three Hundred colonist, was born sometime before 1760, most likely in North Carolina. He married Catherine Hardin of Rutherford County, North Carolina, around 1780–82; they had four sons and three daughters. Gates and his family were in Kentucky by the 1790s. They traveled from Kentucky by way of Miller County, Arkansas, to Stephen F. Austin's colony in Texas in 1821. In April 1824 Gates voted in the election that chose the Baron de Bastrop elector for the colony. Gates received title to two sitios of land now in Washington County on July 16, 1824. Josiah H. Bell surveyed the land for Gates and his son, Amos Gates, five miles below Washington-on-the-Brazos. The census of March 1826 listed William Gates as a farmer and stock raiser aged over fifty. His household at that time included his wife, three sons, and a daughter. One of his sons, Charles, died in 1836. His daughter Sarah married Abner Kuykendall. Catherine Gates died in 1826. William Gates died in Texas on August 20, 1828.