Isham V. Harris, legislator, was born on February 14, 1794, in Warren County, North Carolina, son of Wiley and Elisabeth (Hearne) Harris. He married Nancy Rogers at Reynoldsburg, Humphreys County, Tennessee, around 1824. They moved to Guadalupe County, Texas, in 1850.
He was elected to the Seventh Texas Legislature in 1857 as a representative from Guadalupe County. He and his senate colleague, Henry Eustace McCulloch, caused considerable ire among their constituents when they supported giving up part of Guadalupe County to create Blanco County. The voters voiced their displeasure and did not re-elect Harris to the Eighth Legislature.
Harris died on November 29, 1867, and was buried in the Harris Chapel Cemetery in Guadalupe County.