Asa Hoxey, physician, planter, and soldier of the Republic of Texas, was born in Savannah, Georgia, on February 22, 1800. Soon thereafter his family moved to Wilkes County, Georgia, where he received his earliest education. Upon graduating with honors from the University of Georgia in 1820, Hoxey entered medical school at the University of New York, from which he graduated in 1822. The following year he began his practice in Montgomery, Alabama, where he remained until moving to Texas in 1833. In Alabama he met and married Elizabeth Bennett of New York. The couple had two children, one of whom died of yellow fever while in Confederate service at Galveston.
Hoxey was said to have brought with him $40,000 and thirty slaves. He established two large plantations at the Washington County hamlet of Coles Settlement, later known as Independence. He subsequently built two additional plantations in the Brazos bottoms but abandoned these due to the periodic flooding of the river. With Thomas Gray and John W. Hall, Hoxey organized the Washington Townsite Company to promote the settlement of Washington-on-the-Brazos. In partnership with Gray and a man named Bailey, he entered the mercantile business in Washington, but abandoned the venture as unprofitable.
Hoxey favored Texas independence and served in 1835 as Washington County delegate to the Consultation at Washington-on-the-Brazos, which issued the Texas Declaration of Independence. He also served on the General Council and participated in the siege of Bexar. Although he did not practice medicine after coming to Texas, he served as medical censor during the first administration of President Sam Houston. He was regarded as "a brilliant and delightful conversationalist" and was "an omnivorous but discriminating reader." His home became a favorite meetingplace of the leaders of the republic. He was said to have owned one of the finest private libraries in the republic and contributed liberally to Baylor University during its tenure at Independence. Hoxey was a Mason and a Calhoun Democrat. John Henry Brown characterized him as a man "of dignified and courtly presence, possessed of an intellect of uncommon strength and clearness." He died on May 20, 1863, and his wife died on November 16, 1865.