William Kuykendall, Old Three Hundred settler, the son of Capt. Abner Kuykendall of North Carolina and Sarah (Gates) Kuykendall of Tennessee, was probably born in 1810 when the family was in the Territory of Missouri (Arkansas). The family moved next to southwest Arkansas, near the Red River, and in 1821 from there proceeded to Texas, where they settled west of the Brazos River five miles north of the site of present Brenham on a stream they named New Year Creek. At age sixteen Kuykendall accompanied his father and brothers in patrol of the Old San Antonio Road during the Fredonian Rebellion. After that he participated in protective and retaliatory pursuits of Indians. On April 29, 1828, he received his first land grant of a quarter league (1,107 acres), on the east side of the East Fork of Mill Creek in what is now Austin County. In 1830 he received three-quarters of a league and one labor in Austin County. He married Eliza M. Carothers (Caruthers) on November 6, 1834, by bond in Austin County. They had nine children who survived infancy. Kuykendall received a 640-acre donation grant for his participation in the siege of Bexar in 1835. He also provided both horses and corn to the Army of the Republic of Texas in 1836 and 1838. From July to November 1836 he served as a ranger under Col. Edward Burleson. For this service Kuykendall received three-quarters of a league and a labor of land. The census of 1840 shows him in possession of 3,510 acres of land, one slave, and thirty-five cattle. He also served in the army against Rafael Vásquez in 1842. In the late 1840s Kuykendall settled his family near Mesquite Landing in Refugio County. He died at Hynes Bay on February 27, 1862. His grave has never been found.