Midland College was established as a part of the Permian Junior College System when that system was established in 1969. The college, located in Midland, used facilities of the Midland public schools and had 780 students in the regular term of 1970–71. A bond issue for construction of new buildings was defeated in November 1971, mainly by the voters of Odessa, and Midland College withdrew from the Permian Junior College System and established its own junior college district in 1972. A bond issue of $5.1 million was passed to fund construction on the 115-acre campus. In the fall of 1974 Midland College had an enrollment of 2,135 students, and Al G. Langford was president. In 1975 the Administration Building, the Science Faculty Building, the Maintenance Building, the Learning Resources Center, the Occupational and Technical Building, the Student Center, and the Physical Education Building were completed. In 1978 the Fine Arts Building, an addition to the Occupational and Technical Building, and the Chaparral Center were constructed. Athletes' student housing was added in 1983, and in 1985 the Health Sciences Center was finished. In 1991 the Student Center was doubled in size.
Midland College provides university-parallel education for freshman and sophomore courses, occupational and technical education, community services, and student services. It offers associate and general studies degrees. The college also operates the Midland College Cogdell South Facility in Midland, as well as a Regional Technical Training Center and the Butz Education Center, both in Fort Stockton. The school holds numerous accreditations and memberships, including those with the Texas Higher Education Coordinating Board, the American Association of Community and Junior Colleges, and the Southern Association of Colleges and Schools. In the fall of 1999 David E. Daniel was president, and the enrollment was 4,726 with a faculty of 252.