Miller Creek rises in northwestern Fayette County (at 30°02' N, 96°59' W) about 1½ miles northeast of Winchester and runs southeast for four miles to its mouth (at 29°59' N, 96°58' W) on the Colorado River. In its upper reaches it runs through terrain characterized by a shallow topsoil of loamy sand and a subsoil of heavy clay. In this area agriculture is marginal, and most of the land is covered with a heavy stand of mixed oak, cedar, pine, and yaupon. As it nears the Colorado River, the stream falls into the floodplain, where deep soils of silty loam and clay, though occasionally flooded, produce good crops of corn, pecans, and hay. The name of the creek is probably derived from that of Jacob A. Miller, a settler in the area who joined the volunteer company of Thomas J. Rabb and fought with it during the Ráfael Vásquez raid on San Antonio in 1842.