Milton B. Nuckols (Nuckels, Nichols), a doctor from Kentucky, was one of Stephen F. Austin's Old Three Hundred colonists. On August 3, 1824, he received title to a league and a labor of land now in Matagorda and Brazoria counties. He was living in the San Jacinto vicinity in the fall of 1824, when he signed a petition for appointment of a local surveyor and recommended Dr. Johnson Calhoun Hunter for the position. The census of March 1826 classified Nuckols as a physician, aged between twenty-five and forty. He had a wife, Angelina, and two servants. In September 1826 he was alcalde of San Felipe, and in 1828 Austin expressed the wish that he would be elected síndico procurador for the entire colony. Nuckols probably operated a mercantile business, for James E. B. Austin was paying him for rakes, pots, and griddles in March 1829. Dr. Nuckols died on April 28, 1830, at the home of William Scott on the San Jacinto River.